|
KMID : 0389420110190030243
|
|
Korean Journal of Stress Research
2011 Volume.19 No. 3 p.243 ~ p.251
|
|
|
Various Types of Stress Deteriorate Spatial Memory through Inhibition of Cell Proliferation in the Hippocampus of Rats
|
|
Yoon Jee-Sang
Baik Hyung-Hwan
Lee Su-Shin
Heo Yu-Mi
Kim Bo-Kyun
Shin Mal-Soon
Lee Sang-Won
Kim Chang-Ju
|
|
|
Abstract
|
|
|
|
Stress is defined as physical, physiological, and psychological modifications that disrupt the homeostasis and internal balance of the body. Stress is closely associated with neuronal changes such as impaired neurogenesis, neuronal atrophy, and neuronal apoptosis in the hippocampus. In the present study, we investigated the effects of various types of stress (restraint stress, noise stress, cold stress) on spatial memory, cell proliferation, and expression of brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (TrkB) in the hippocampus of rats. The rats in the restraint stress group were restrained in a transparent cylinder. The rats in the noise stress group were exposed to a 120 dB supersonic machine sound. The rats in the cold stress group were exposed to a cold chamber at 4oC. The rats in the control group were left undisturbed. Application of each stress was conducted for 60 min 2 times a day, and continued for 10 days. In the present results, all three types of stress induced spatial memory impairment. All three types of stress suppressed cell proliferation and inhibited expression of BDNF and TrkB in the hippocampus. The strength of the deteriorating and suppressing effects of stresses had the following rank order: restraint stress＞noise stress＞cold stress. Thus, impairment of spatial memory by stresses may be due to the inhibition of cell proliferation through suppressing BDNF expression in the hippocampus.
|
|
|
KEYWORD
|
|
|
Restraint stress, Noise stress, Cold stress, Spatial memory, Hippocampus
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|